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FIGURE 3. Correlation between KAD or BED, and the loss in CLR. (A) KADStdVol computed by MIRDOSE3.1 KADStdVol. (B) KADCTVol computed by MIRD Pamphlet 19. (C) Correlation between BED and current CLR loss per year. (D) Correlation between BED and percentage of CLR loss after 18-mo follow-up. Size of symbols reflects number of treatment cycles received by each patient (from 1 for smallest to 5 for largest). Points were fitted to power exponential function (see Eq. 4 in text). In C, note clear difference in BED values observed between patients with rapid CLR decline (CLR loss per year >20%) compared with those with a slower decline.