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FIGURE 3. (A) Survival curves of groups of rats (n = 8–15), each bearing both a small (approximately 0.5 cm2) and a large (7–9 cm2) somatostatin receptor-positive rat pancreatic CA20948 tumor in the flanks. Rats were treated with 2 intravenous administrations (2 wk apart) of 2 x 111 MBq 90Y-DOTATOC (indicated as 90Y), 2 x 278 MBq 177Lu-DOTATATE (indicated as 177Lu), or 2 x 56 MBq 90Y-DOTATOC plus 2 x 140 MBq 177Lu-DOTATATE (indicated as 177Lu + 90Y). Control rats did not receive radioactivity. (B) Bars indicate the criteria for euthanasia. Rats were sacrificed when size of large tumors, small tumors, or both tumors exceeded 15 cm2. When neither tumor grew, animals were sacrificed at day 150 after therapy.
