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FIGURE 3. The next generation of radionuclide targeting; examples of pretargeting approaches: (A) Two-step streptavidin IgG/radiolabeled biotin procedure (177,191). (B) Three-step biotinylated IgG/radiolabeled biotin pretargeting procedure (160,161). (C) Bispecific antibody pretargeting procedure (164). (D) Oligonuclide pretargeting procedure (165–167).

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