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FIGURE 3. SPM of 18F-MPPF binding by decade of age (analysis III). (A and B) SPM of differences between decades in female population. (A) Decrease in 18F-MPPF binding between subjects in their 40s and their 50s in right superior temporal gyrus (sagittal view, x = 54 mm; transverse view, z = –8 mm). (B) Increase in 18F-MPPF binding from 50s to 60s decades of age in left fusiform gyrus (sagittal view, x = –44 mm; coronal view, y = –70 mm). (C and D) SPM of differences between decade of age in male population: decrease in 18F-MPPF binding between subjects in their 20s and 30s. (C) Sagittal view (x = –10 mm): Decrease in left posterior cingulate gyrus (cross), superior parietal lobule, and superior frontal gyrus. (D) Transverse view (z = +44 mm), decrease in left inferior parietal lobule (cross). BP values appear symmetric in right inferior parietal, left posterior cingulate, and left middle frontal cortex. (E and F) SPM of differences between decades in female population: Increase in 18F-MPPF binding between subjects in their 30s and 40s. (E) Sagittal view (x = +6 mm), right middle frontal gyrus (BA 9). (F) Transverse view (z = 32 mm), left middle frontal gyrus.
