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FIGURE 2. SPM of 18F-MPPF binding with age and sex effect (analysis II). (A and B) Increase in 18F-MPPF binding in female compared with male subjects independently of age effect. (A) Maximum intensity projection (MIP) in the x-, y-, and z-directions of the statistical map. t score threshold P < 0.001 uncorrected for multiple comparisons; cluster threshold P < 0.05 corrected for multiple comparisons. Right of the brain is the right of the figure. (B) Three orthogonal views (x, y, z = 66, –22, –14) of SPM centered on peak situated in right middle temporal gyrus (Boadmann’s area [BA] 21) superimposed on averaged normalized MR images from 23 female subjects. Right hippocampus is visible on right hemisphere in transverse and coronal views. (C) Binding of 18F-MPPF increase in male vs. female independent of age effect. Transverse view of SPM shows a side effect in surface of parietal cortex (x, y, z = 36, –78, 46). (D and E) Negative linear correlation of BP with age in female subjects. (D) MIP of statistical map. t score’s threshold P < 0.001 uncorrected for multiple comparisons; cluster threshold P < 0.05 corrected for multiple comparisons. (E) Three orthogonal views of SPM centered on peak situated in right superior temporal gyrus (x, y, z = 48, –19, –5; BA 22) superimposed on averaged normalized MR images from 23 female subjects. (F) Positive linear correlation of BP with age in male population. Three orthogonal views of SPM (t threshold P < 0.001 uncorrected; cluster threshold P < 0.05 corrected, x, y, z = –8, 64, –18) centered on peak situated in left middle frontal gyrus (BA 11) superimposed on averaged normalized MR images from 22 male subjects. Rectus gyrus is visible on sagittal and transverse views.
