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FIGURE 1. Representative VOIs defined on an SPGR MR image of an AD subject (A-3). Shown in white are enhanced examples of cortical ROIs examined in this study: ANC = anterior cingulate; FRT = frontal; LTC = lateral temporal; MTC = mesial temporal; OCC occipital; PAR = parietal; PCG = posterior cingulate. Also shown is CER (cerebellum reference region) and a carotid ROI (CAR) defined bilaterally over internal carotid artery on an early summed PIB PET scan (initial 45 s of acquisition).