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FIGURE 7. Representative measured and fitted time–activity curves from patient 7 (Figs. 1A and Tables 3 and 4). (A) Time–activity curve from tumor region with increased 18F-FLT uptake; simple mean reduced 
2 value for fit without k4 is 241.1 and with k4 is 250.6. (B) Time–activity curve from blood. (C) Time–activity curve from contralateral control region; simple mean reduced 2 value for fit without k4 is 130.3 and with k4 is 134.9. Fifteen minutes or more after radiotracer administration, tumor-to-blood ratio is significantly higher than 1, supporting hypothesis that 18F-FLT uptake is at least partly determined by 18F-FLT trapping and TK1 activity.
