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FIGURE 3. Two examples of complementary information on activity and extent of tumor as depicted by multimodal imaging. (A) A 49-y-old woman with recurrent glioblastoma that had been treated by operation, radiation, and 5 cycles of temozolomide. 18F-FLT seems to depict some extension of tumor toward internal capsule and thalamus that was not clearly depicted by gadolinium MRI and 11C-MET PET. Contours on MRI depict tumor extent as measured by 18F-FLT PET; contours on 11C-MET and 18F-FLT PET depict tumor extent as measured by gadolinium enhancement. (B) A 58-y-old woman with WHO grade III ganglioglioma. High tumor activity is depicted by high 18F-FLT uptake (uptake ratio, 13.0; SUV, 3.0), which exceeds involvement shown by gadolinium enhancement to lateral side (volume, 40 cm3 vs. 14.4 cm3). 11C-MET PET shows even further extension of tumor toward pole of temporal lobe. Contours on MRI depict tumor extent as measured by 18F-FLT PET; contours on 18F-FLT PET depict tumor extent as measured by gadolinium enhancement.
