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FIGURE 2. False-negative findings on 18F-FLT PET in 50-y-old woman with WHO grade II astrocytoma that had been resected at primary diagnosis. At a regular follow-up, MRI depicted signal changes within large parts of left hemisphere with only minor gadolinium enhancement (volume, 1.2 cm3) and area of mildly increased 11C-MET uptake (volume, 5.7 cm3; factor, 1.6). Mucosa and cranial bone marrow show intense 18F-FLT uptake, whereas 18F-FLT background in normal brain is low.