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FIGURE 1. Factors influencing uptake of RGD-peptide-polymer conjugates: expression of 
vß3 integrins on tumor cells and vasculature (1), formation of clusters of activated vß3 integrins (2), enhanced permeability (3), impaired lymphatic drainage result in EPR (4), nonspecific tumor accumulation of peptide-polymer conjugates by EPR (5), nonspecific uptake in nontumor tissue (6), blood clearance (kinetics) (7), catabolism (8), and whole-body-retention and excretion kinetics (9).
