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FIGURE 2. Typical serial transaxial small animal ¹⁸F-FAZA PET scans of 2 Swiss nude mice bearing subcutaneous A431 tumors at right side of thorax. Note decreased tracer uptake after breathing 100% O₂ for 8 h. ROI analyses, as shown in experiment 1 (Exp. 1), revealed that the mean T/Bk ratio decreased from 4.7:1 (breathing room air) to 3.7:1 (breathing 100% O₂) in experiment 1 and from 11.3:1 to 5.4:1 in experiment 2 (Exp. 2), respectively.

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