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FIGURE 9. Electron microscopy and modeling of ferumoxtran-10. (A and B) Electron micrographs of superparamagnetic hexagonal nanoparticle crystal measuring 3 nm on average (A, bar = 10 nm; B, bar = 1 nm). (C and D) Molecular model of surface-bound 10-kDa dextrans (overall mean particle size, 28 nm) and iron oxide crystal packing. (E) Mechanism of action. Systemically injected long circulating particles gain access to interstitium and are drained ubiquitously through lymphatic vessels. Lymph flow disturbances or disturbances of nodal architecture by metastases lead to abnormal accumulation patterns, detectable by MRI. (Reprinted with permission of (71).)
