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FIGURE 10. Spectrum of nodal signal intensity changes with magnetic nanoparticles. (A–C) Normal lymph node in left iliac region on noncontrast MR image (A) and 24 h after intravenous administration of ferumoxtran-10 (arrow) (B). Note homogeneous decrease in signal intensity due to ferumoxtran-10 accumulation. (C) Corresponding histology (10x objective). (D–F) Nonenlarged iliac lymph node completely replaced by tumor (arrow). (D) Conventional MR image shows high-signal-intensity lymph node. (E) Twenty-four hours after ferumoxtran-10 administration. Note that nodal signal intensity remains high. (F) Corresponding histology. (G–I) Micrometasases in retroperitoneal node. (G) MR image shows high-signal-intensity lymph node. (H) Ferumoxtran-10–enhanced MR image demonstrates 2 hyperintense foci (arrows) within node corresponding to 2-mm metastases. (I) Corresponding histology confirms presence of adenocarcainoma within node. (Reprinted with permission of (71).)
