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FIGURE 1. Estimation of white matter activity for 3S-PVC (Eq. 2) from a ¹¹C-AA PET frame (25–30 min after injection). Activity values for pure white matter were obtained from voxels with smoothed white matter mask value (s_WM) close to 1.0. Each point represents mean ± SD of activity in voxels plotted vs. smoothed white matter mask. Activity values of voxels with s_WM from 0.99 to 1.0 were fitted to straight line and value at s_WM = 1.0 was used as white matter value.

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