Journal of Nuclear Medicine Vol. 45 No. 7 13A-14A
© 2004 by Society of Nuclear Medicine
This Month in JNM
Weber looks at the sometimes-puzzling phenomenon of brown-fat radiotracer uptake and recent innovations that promise to resolve some of the imaging difficulties it has posed for nuclear medicine specialists.
Page 1101
Goldsmith comments on difficulties in establishing the relationship between radiation-absorbed dose and radiobiologic response and advocates the determination of the microdosimetry of tracers on a microscopic and histopathologic scale.
Page 1104
Strauss et al. assess current research on the relationship of 18F-FDG localization to macrophage activity in atherosclerosis and note that this relationship is likely to be a key to predicting significant cardiac events.
Page 1106
Kasama et al. present scintigraphic and other evidence suggesting that atrial natriuretic peptide can benefit cardiac sympathetic nerve activity and improve left ventricular remodeling in patients with acute heart failure.
Page 1108
Kurata et al. report on a study using 123I-MIBG imaging to determine whether kidney transplantation improves cardiac sympathetic nervous system function.
Page 1114
Akashi et al. used 123I-MIBG myocardial scintigraphy to uncover significant clues to the origins of reversible left ventricular dysfunction in patients with "takotsubo" cardiomyopathy.
Page 1121
Slomka et al. introduce a novel "motion-frozen" technique to improve the image quality and accuracy of gated myocardial perfusion SPECT by eliminating the influence of cardiac left ventricular motion on display and quantification.
Page 1128
Whone et al. discuss the results of a large, multiinstitutional study of 18F-DOPA PET scans of patients with Parkinson’s disease, in an effort to provide centralized assessment of biomarkers of disease progression and therapy.
Page 1135
Levivier et al. outline a technique that allows routine integration of functional PET data with stereotactic 
-knife neurosurgery in the treatment of brain tumors.
Page 1146
Simonian et al. report on a dual-isotope technique for simultaneous measurement of gastric emptying and accommodation in a single test that could prove beneficial for patients with upper gastrointestinal symptoms.
Page 1155
Becherer et al. compare 18F-FDOPA PET and 111In-labeled somatostatin receptor scintigraphy in imaging and staging of neuroendocrine tumors.
Page 1161
de Jong et al. critique the assumption of homogeneous renal radioactivity in dose calculations for injected tracers and note the inadequacy of these assumptions for calculations in peptide receptor radionuclide therapy.
Page 1168
Kushner presents a continuing education review of clinical presentation, staging, prognosis, treatment, and nuclear medicine imaging options in neuroblastoma.
Page 1172
Tatsumi et al. report on the result of a study in rodents suggesting that drugs and environmental conditions can affect the high 18F-FDG uptake of brown adipose tissue and suggest that such variables be considered routinely.
Page 1189
Sakuma et al. look at 99mTc labeling of myocardial microthromboemboli to provide both diagnostic and prognostic information on patients undergoing primary percutaneous transluminal coronary angioplasty.
Page 1194
Rusckowski et al. present evidence that 99mTc-labeled bacteriophages may exhibit specific binding to bacteria and bacterial fragments, suggesting the possibility of effective imaging for both diagnosis of infection and assessment of treatment.
Page 1201
Siaens et al. discuss the feasibility of and initial animal studies in SPECT of fungal infections with 123I-labeled chitinase, a bacterium-derived enzyme.
Page 1209
Rennen et al. investigate affinities to receptors on neutrophils and their suitability for infection imaging and suggest possible avenues for additional research.
Page 1217
Koppe et al. detail the characteristics of a range of radionuclides and their potential for use in radioimmunotherapy of small peritoneal metastases of colorectal origin.
Page 1224
Seltzer et al. provide new estimates for 11C-acetate dosimetry in dynamic whole-body PET, suggesting that current recommended limits can be raised to improve overall image quality and tumor detection.
Page 1233
González Trotter et al. assess the feasibility of quantitative murine 124I-antibody fragment PET using a large-bore clinical scanner that accommodates multiple animals simultaneously.
Page 1237
Ogawa et al. investigate the role of macrophages in 18F-FDG accumulation in atherosclerotic lesions and the utility of PET in identifying vulnerable plaques.
Page 1245
Liu et al. present a novel technique using 99mTc-glucarate high-resolution SPECT for assessing the severity of myocardial injury induced by ischemia–reperfusion and point to possible applications in kinetic studies of new myocardial imaging agents.
Page 1251
Konijnenberg et al. present a computational rat model to facilitate and standardize organ dosimetry studies of peptide receptor radionuclide therapy and offer conclusions from initial calculations for 111In, 117Lu, and 90Y.
Page 1260
| ON THE COVER
The "motion-frozen" technique improves the display and quantification of gated myocardial perfusion SPECT images. Three-dimensional phase-to-phase motion vectors are derived by sampling the epi- and endocardial surfaces. In this illustration of displacement vectors used in image warping, the end-systolic epicardial surface is shown with perfusion data represented in color. Displacement vectors (white) show local motion between end systole and end diastole. The end-diastolic position of the epicardial surface is marked with red points.
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Related articles in JNM:
- Brown Adipose Tissue and Nuclear Medicine Imaging
- Wolfgang A. Weber
JNM 2004 45: 1101-1103.
[Full Text]
- Improving Insight into Radiobiology and Radionuclide Therapy
- Stanley J. Goldsmith
JNM 2004 45: 1104-1105.
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- Imaging the Vulnerable Plaque: A Scintillating Light at the End of the Tunnel?
- H. William Strauss, Mark Dunphy, and Naoki Tokita
JNM 2004 45: 1106-1107.
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- Effects of Intravenous Atrial Natriuretic Peptide on Cardiac Sympathetic Nerve Activity in Patients with Decompensated Congestive Heart Failure
- Shu Kasama, Takuji Toyama, Hisao Kumakura, Yoshiaki Takayama, Takehiro Ishikawa, Shuichi Ichikawa, Tadashi Suzuki, and Masahiko Kurabayashi
JNM 2004 45: 1108-1113.
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- Improvement of Cardiac Sympathetic Innervation by Renal Transplantation
- Chinori Kurata, Akihiko Uehara, and Akira Ishikawa
JNM 2004 45: 1114-1120.
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- 123I-MIBG Myocardial Scintigraphy in Patients with "Takotsubo" Cardiomyopathy
- Yoshihiro J. Akashi, Kiyoshi Nakazawa, Masayoshi Sakakibara, Fumihiko Miyake, Haruki Musha, and Kaoru Sasaka
JNM 2004 45: 1121-1127.
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- "Motion-Frozen" Display and Quantification of Myocardial Perfusion
- Piotr J. Slomka, Hidetaka Nishina, Daniel S. Berman, Xingping Kang, Cigdem Akincioglu, John D. Friedman, Sean W. Hayes, Usaf E. Aladl, and Guido Germano
JNM 2004 45: 1128-1134.
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- A Technique for Standardized Central Analysis of 6-18F-Fluoro-L-DOPA PET Data from a Multicenter Study
- Alan L. Whone, Dale L. Bailey, Philippe Remy, Nicola Pavese, and David J. Brooks
JNM 2004 45: 1135-1145.
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- Use of Stereotactic PET Images in Dosimetry Planning of Radiosurgery for Brain Tumors: Clinical Experience and Proposed Classification
- Marc Levivier, Nicolas Massager, David Wikler, José Lorenzoni, Salvador Ruiz, Daniel Devriendt, Philippe David, Françoise Desmedt, Stéphane Simon, Paul Van Houtte, Jacques Brotchi, and Serge Goldman
JNM 2004 45: 1146-1154.
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- Simultaneous Assessment of Gastric Accommodation and Emptying: Studies with Liquid and Solid Meals
- Hrair P. Simonian, Alan H. Maurer, Linda C. Knight, Steve Kantor, Despina Kontos, Vasileios Megalooikonomou, Robert S. Fisher, and Henry P. Parkman
JNM 2004 45: 1155-1160.
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- Imaging of Advanced Neuroendocrine Tumors with 18F-FDOPA PET
- Alexander Becherer, Monica Szabó, Georgios Karanikas, Patrick Wunderbaldinger, Peter Angelberger, Markus Raderer, Amir Kurtaran, Robert Dudczak, and Kurt Kletter
JNM 2004 45: 1161-1167.
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- Inhomogeneous Localization of Radioactivity in the Human Kidney After Injection of [111In-DTPA]Octreotide
- Marion de Jong, Roelf Valkema, Arthur van Gameren, Hester van Boven, Axel Bex, Eric Pieter van de Weyer, Jan Dirk Burggraaf, Meike Körner, Jean-Claude Reubi, and Eric P. Krenning
JNM 2004 45: 1168-1171.
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- Neuroblastoma: A Disease Requiring a Multitude of Imaging Studies
- Brian H. Kushner
JNM 2004 45: 1172-1188.
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- Intense 18F-FDG Uptake in Brown Fat Can Be Reduced Pharmacologically
- Mitsuaki Tatsumi, James M. Engles, Takayoshi Ishimori, O’Bod Nicely, Christian Cohade, and Richard L. Wahl
JNM 2004 45: 1189-1193.
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- Molecular Imaging Identifies Regions with Microthromboemboli During Primary Angioplasty in Acute Coronary Thrombosis
- Tadamichi Sakuma, Jiri Sklenar, Howard Leong-Poi, Norman C. Goodman, David K. Glover, and Sanjiv Kaul
JNM 2004 45: 1194-1200.
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- Investigations of a 99mTc-Labeled Bacteriophage as a Potential Infection-Specific Imaging Agent
- Mary Rusckowski, Suresh Gupta, Guozheng Liu, Shuping Dou, and Donald J Hnatowich
JNM 2004 45: 1201-1208.
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- 123I-Labeled Chitinase as Specific Radioligand for In Vivo Detection of Fungal Infections in Mice
- Rien Siaens, Vincent G.H. Eijsink, Rudi Dierckx, and Guido Slegers
JNM 2004 45: 1209-1216.
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- Relationship Between Neutrophil-Binding Affinity and Suitability for Infection Imaging: Comparison of 99mTc-Labeled NAP-2 (CXCL-7) and 3 C-Terminally Truncated Isoforms
- Huub J.J.M. Rennen, Cathelijne Frielink, Ernst Brandt, Sebastian A.J. Zaat, Otto C. Boerman, Wim J.G. Oyen, and Frans H.M. Corstens
JNM 2004 45: 1217-1223.
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- Biodistribution and Therapeutic Efficacy of 125/131I-, 186Re-, 88/90Y-, or 177Lu-Labeled Monoclonal Antibody MN-14 to Carcinoembryonic Antigen in Mice with Small Peritoneal Metastases of Colorectal Origin
- Manuel J. Koppe, Robert P. Bleichrodt, Annemieke C. Soede, Albert A. Verhofstad, David M. Goldenberg, Wim J.G. Oyen, and Otto C. Boerman
JNM 2004 45: 1224-1232.
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- Radiation Dose Estimates in Humans for 11C-Acetate Whole-Body PET
- Marc A. Seltzer, Shamim A. Jahan, Richard Sparks, David B. Stout, Nagichettiar Satyamurthy, Magnus Dahlbom, Michael E. Phelps, and Jorge R. Barrio
JNM 2004 45: 1233-1236.
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- Quantitation of Small-Animal 124I Activity Distributions Using a Clinical PET/CT Scanner
- Dinko E. González Trotter, Ravindra M. Manjeshwar, Mohan Doss, Calvin Shaller, Matthew K. Robinson, Reeti Tandon, Gregory P. Adams, and Lee P. Adler
JNM 2004 45: 1237-1244.
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- 18F-FDG Accumulation in Atherosclerotic Plaques: Immunohistochemical and PET Imaging Study
- Mikako Ogawa, Seigo Ishino, Takahiro Mukai, Daigo Asano, Noboru Teramoto, Hiroshi Watabe, Nobuyuki Kudomi, Masashi Shiomi, Yasuhiro Magata, Hidehiro Iida, and Hideo Saji
JNM 2004 45: 1245-1250.
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- High-Resolution Imaging with 99mTc-Glucarate for Assessing Myocardial Injury in Rat Heart Models Exposed to Different Durations of Ischemia with Reperfusion
- Zhonglin Liu, Harrison H. Barrett, Gail D. Stevenson, George A. Kastis, Michael Bettan, Lars R. Furenlid, Donald W. Wilson, and Koon Yan Pak
JNM 2004 45: 1251-1259.
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- A Stylized Computational Model of the Rat for Organ Dosimetry in Support of Preclinical Evaluations of Peptide Receptor Radionuclide Therapy with 90Y, 111In, or 177Lu
- Mark W. Konijnenberg, Magda Bijster, Eric P. Krenning, and Marion de Jong
JNM 2004 45: 1260-1269.
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