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FIGURE 9. Quantitation of reporter gene expression during permeability edema. (A) Relationship between lung uptake of 18F-FHBG and mHSV1-TK enzyme activity in 9 rats with ANTU-induced increase in pulmonary vascular permeability. (B and C) Relationship between total lung uptake (expressed as %ID in whole lung) and normalized lung weight in 9 rats with ANTU-induced increases in pulmonary vascular permeability (B) and in 9 normal rats (C). {circ}, Data points obtained in rats infected with Ad-CMV-mNLS-HSV1sr39tk-egfp. •, Data points obtained in animals infected with control virus. Regression line is displayed when significant linear correlation was obtained. PCV = penciclovir; b.w. = body weight.





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