Click on image to view larger version.
FIGURE 6. Examples of curve fitting using compartmental modeling obtained in 2 rats infected with Ad-CMV-mNLS-HSV1sr39tk-egfp (A) and with null vector (B), respectively. Blood (
) and lung (•) time–activity curves are displayed. Continuous line represents fitted lung data points using 3-compartment model shown in Figure 2. (C and D) Corresponding plots of residuals over time from regression analysis. CM Ki = influx constant calculated from individual rate constants shown in Figure 2 (see Eq. 3); BV = blood volume expressed as percentage of ROI volume.
