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FIGURE 3. Quantitation of mHSV1-TK enzyme activity (A), eGFP levels (B), and ¹⁸F-FHBG lung uptake (C) as function of viral dose in 9 rats without lung injury. , Mean values at each of viral doses of Ad-CMV-mNLS-HSV1sr39tk-egfp (5 x 10⁹ VP [n = 2 rats], 1 x 10¹⁰ VP [n = 2 rats], 5 x 10¹⁰ VP [n = 3 rats]). •, Mean values measured in control animals (n = 2). Bars are SDs. Linear regression was performed on data points from all rats and corresponding regression line is displayed when slope was statistically significant compared with slope of zero. PCV = penciclovir.

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