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FIGURE 2. Diagram of 3-compartment model representing ¹⁸F-FHBG kinetics within lungs. In this model, K₁ and k₂ are rate constants representing transport of ¹⁸F-FHBG into and out of cells, and k₃ represents rate of phosphorylation of ¹⁸F-FHBG in cells expressing viral TK. Since ¹⁸F-FHBG-P is assumed to be trapped intracellularly, k₄ (rate constant representing ¹⁸F-FHBG dephosphorylation) was not included in model.

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