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FIGURE 1. Generation of pulmonary time–activity curve from multiple-image dataset from 1 experimental animal. Pulmonary ROIs are drawn on multiple transverse slices of PET image and subsequently merged to obtain measurement of pulmonary radioactivity originating from whole lung volume at time of PET image data acquisition. These ROIs are then superimposed on images obtained at each sampling time with PET, to generate lung time–activity curve. For clarity, only 1 of multiple transverse thoracic slices is displayed at 6 of 37 time points. Color scale is shown on top of each PET image and expressed as percentage of 18F-FHBG injected dose. ID = injected dose.
