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FIGURE 2. Representative gated SPECT images from good responders (A) and poor responders (B). Shown are ungated perfusion polar maps before therapy (left panels) and serial 3-dimensional displays of end-diastolic (grid) and end-systolic (solid) surfaces from a right anterior oblique 30° view (middle and right panels). Small perfusion defects are present in apical and posterior myocardium of good responders (extent of defect, 4%). Three-dimensional displays show that LV shape is preserved as a prolate ellipse (sphericity index, 1.7). LVEF increased by 33% after ß-blocker therapy. In contrast, multiple perfusion defects were observed in poor responders (extent of defect, 11%) and the LV cavity is spheric (sphericity index, 1.3). LVEF increased by only 6% after 4 mo of ß-blocker therapy.
