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FIGURE 2. Activity in tissues that did not significantly express NIS (liver, muscle, spleen, kidney). Error bars represent 1 SD. The y-axis scale is similar to that of blood (Fig. 1). The 3 radiopharmaceuticals showed similar patterns of uptake. Activities were lower than those of blood and sequentially decreased over time. Addition of perchlorate did not diminish activity and, in fact, resulted in a modest increase in renal activity at 20 min, probably the result of a reduction in uptake by competing NIS-dependent pathways.
