Journal of Nuclear Medicine Vol. 45 No. 12 8A-9A
© 2004 by Society of Nuclear Medicine
THIS MONTH IN JNM
Slomka looks at the significance of SPECT-derived quantitative assessment of changes in myocardial perfusion over time and, specifically, after therapy and previews an innovative approach reported in this month’s JNM.
Page 1978
Itti and colleagues report on voxel-based automated myocardial perfusion scintigraphy quantification methods that more accurately assess change after myocardial infarction and therapy.
Page 1981
Okumura and colleagues investigate the relative usefulness of fasting 18F-FDG PET in detecting inflammatory lesions of early-stage cardiac sarcoidosis.
Page 1989
Abidov and colleagues derive and validate the normal threshold for automatically measured left ventricular transient ischemic dilation ratios in patients referred for adenosine stress myocardial perfusion SPECT and consider the integration of these data into routine assessment of coronary artery disease.
Page 1999
Lubberink and colleagues compare the quantitative accuracy of iteratively reconstructed cardiac 18F-FDG PET with that of filtered backprojection for both 2- and 3-dimensional acquisitions to establish an optimal procedure for PET imaging of myocardial viability.
Page 2008
Schaefer and colleagues contrast a range of prone and supine patient positioning values acquired during gated 99mTc-myocardial SPECT and discuss the implications for comparing such values with standard reference data.
Page 2016
Oommen and colleagues assess the use of specific patterns identified on interictal and postictal SPECT to improve localization of epileptogenic foci in the temporal lobe.
Page 2021
El Fakhri and colleagues look at the beneficial effects of improved quantitative image reconstruction with compensation for scatter, attenuation, and variable collimator response on reader performance in discrimination tasks related to the diagnosis of prodromal Alzheimer’s disease.
Page 2026
Roivainen and colleagues report on metabolism and whole-body distribution of intravenously administered 11C-MP4B, a new radiopharmaceutical for PET assessment of butyrylcholinesterase activity.
Page 2032
Wilczek and colleagues compare the abilities of 99mTc-exametazime with those of 99mTc-sestamibi as mammoscintigraphic tumor-imaging radiopharmaceuticals.
Page 2040
Israel and colleagues evaluate the incremental role of 18F-FDG PET/CT in the diagnosis and management of cancer patients with increasing levels of tumor markers as the sole indicator of potential recurrence after initial successful treatment.
Page 2045
de Boer and colleagues assess whether quantitative 11C-TYR PET has predictive value for survival and therapy outcome in patients with primary squamous cell carcinoma of the larynx.
Page 2052
Kumar and colleagues report on the role and additional benefits of 18F-FDG PET in differentiating benign from metastatic adrenal masses detected on CT or MRI in patients with lung cancer.
Page 2058
Alauddin and colleagues investigate the biodistribution and uptake characteristics of 18F-FFAU, a potentially superior PET agent for HSV1-tk gene expression imaging.
Page 2063
Tian and colleagues describe the detection of cancer gene activity from outside the body by probing with radionuclide-chelator-peptic nucleic acid-peptide chimeras, a technique that could help to avoid unnecessary biopsies.
Page 2070
Takei and colleagues use an experimental model to determine the best timing for detecting apoptosis in vivo with 99mTc-annexin V after chemotherapy.
Page 2083
Siaens and colleagues assess differences and similarities in 2 labeled quinolones, 99mTc-ciprofloxacin and 99mTc-enrofloxacin, as tracers for infection and inflammation in animals.
Page 2088
Hatada and colleagues report on the myocardial uptake and clearance kinetics 99mTc-N-DBODC5, a new myocardial perfusion tracer with superior biodistribution properties that promise to markedly reduce photon scatter problems in myocardial images.
Page 2095
Zanzonico and colleagues investigate the effects of continuing antithyroid drugs at a reduced dosage during 131I therapy to reduce extrathyroid radiation without significantly reducing the target tissue dose.
Page 2102
Shin and colleagues develop a dual-imaging reporter gene system and examine the correlation between cancer cell number and signals from 2 reporter genes, a method that could be used to evaluate the effects of various therapeutic approaches.
Page 2109
Bergmann and colleagues elucidate the tumor cell transport mechanism for a novel 18F-labeled phenylalanine derivative that is presented as a potential PET tracer for imaging of amino acid transport intumors.
Page 2116
| ON THE COVER
This whole-body PET image of a healthy male volunteer shows that most of the radioactivity is distributed in the urinary bladder, indicating prompt excretion through the renal system. Renal pelvis, stomach, salivary glands, liver, kidneys, spleen, and vertebral column were also clearly visualized. However, uptake in myocardium, pancreas, and lungs was low. The distribution of 11C-MP4B in the brains of patients with Alzheimer’s disease appears to be in accordance with the distribution of butyrylcholinesterase seen in postmortem studies of human brain, except for an observed higher activity in striatum than in cortex
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Related articles in JNM:
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JNM 2004 45: 1978-1980.
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- Assessment of Myocardial Reperfusion After Myocardial Infarction Using Automatic 3-Dimensional Quantification and Template Matching
- Emmanuel Itti, Gregory Klein, Jean Rosso, Eva Evangelista, Jean-Luc Monin, Pascal Gueret, Michel Meignan, and Jean-Philippe Thirion
JNM 2004 45: 1981-1988.
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- Usefulness of Fasting 18F-FDG PET in Identification of Cardiac Sarcoidosis
- Wataru Okumura, Tsutomu Iwasaki, Takuji Toyama, Tatsuya Iso, Masashi Arai, Noboru Oriuchi, Keigo Endo, Tomoyuki Yokoyama, Tadashi Suzuki, and Masahiko Kurabayashi
JNM 2004 45: 1989-1998.
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- Integration of Automatically Measured Transient Ischemic Dilation Ratio into Interpretation of Adenosine Stress Myocardial Perfusion SPECT for Detection of Severe and Extensive CAD
- Aiden Abidov, Jeroen J. Bax, Sean W. Hayes, Ishac Cohen, Hidetaka Nishina, Shunichi Yoda, Xingping Kang, Fatma Aboul-Enein, James Gerlach, John D. Friedman, Rory Hachamovitch, Guido Germano, and Daniel S. Berman
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- Quantitative Comparison of Analytic and Iterative Reconstruction Methods in 2- and 3-Dimensional Dynamic Cardiac 18F-FDG PET
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JNM 2004 45: 2008-2015.
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- Wolfgang M. Schaefer, Claudia S.A. Lipke, Harald P. Kühl, Karl-Christian Koch, Hans-Juergen Kaiser, Patrick Reinartz, Bernd Nowak, and Udalrich Buell
JNM 2004 45: 2016-2020.
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JNM 2004 45: 2058-2062.
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- Mian M. Alauddin, Antranic Shahinian, Ryan Park, Michel Tohme, John D. Fissekis, and Peter S. Conti
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JNM 2004 45: 2083-2087.
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JNM 2004 45: 2088-2094.
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- Kengo Hatada, Laurent M. Riou, Mirta Ruiz, Yoshihiro Yamamichi, Adriano Duatti, Ronaldo L. Lima, Allen R. Goode, Denny D. Watson, George A. Beller, and David K. Glover
JNM 2004 45: 2095-2101.
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