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FIGURE 3. Internalization experiment using CC2B, JY, TMM, APD, and B-CLL cells. Cells were incubated either with [125I-Tyr3]octreotide alone or with [125I-Tyr3]octreotide and excess of unlabeled octreotide (1 µmol/L) for 30, 60, and 120 min, respectively. At each time point, internalization was measured. Results are presented as amount of radiolabeled compound internalized by cell in fmol/106 cells and as degree of internalization for 106 cells as percentage of administered dose.
