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FIGURE 5. PET imaging of melanoma-bearing mice with 68Ga-DOTA-NAPamide. (A and B) Scatter- and attenuation-corrected PET images of melanoma-bearing mice. 68Ga-DOTA-NAPamide (50.1 GBq/µmol; 40 pmol) was injected into mice implanted in right flank with B16F1 melanoma and imaged at 0.5, 1, 2, and 3 h after injection (n = 2): coronal image (A) and transaxial image (B) of mice 0.5 h (tumor weight, 300 mg) and 1 h (tumor weight, 344 mg) after injection. Only melanoma, kidneys, bladder, and, to a lesser extent, heart are detectable. No further background reduction could be observed at later time points. (C) Kinetics of tumor and kidney uptake. Melanoma-bearing mice were injected with either 40 pmol (50.1 GBq/µmol) or 290 pmol (16.5 GBq/µmol) 68Ga-DOTA-NAPamide. Melanoma and kidneys were collected 0.5, 1, 2, and 3 h after injection and radioactivity was measured in 
-counter. Results are expressed as %ID/g tissue (mean ± SEM; n = 2–4). 
P < 0.001 vs. 290 pmol.
