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FIGURE 4. Autoradiographs of tissue sections from primary and metastatic melanoma. (A) Lung with melanotic melanoma metastases. (B) Lung with melanotic or amelanotic melanoma metastases. (C and D) Liver with melanotic melanoma metastases. (E) Primary melanoma with surrounding skin tissue. 67Ga-DOTA-NAPamide was injected into tumor-bearing mice. Primary skin melanoma and tissues showing macroscopic metastases were collected 4 h later and immediately fixed. After sectioning, tissues were exposed to Molecular Dynamics Storage Phosphor Plate (left) and later were exposed to scanner (right). Arrows indicate amelanotic (dotted arrow) or melanotic (solid arrows) metastatic nodules.
