FIGURE 1. Histologic analysis of spleen obtained from SCID mouse engrafted with primary Ph⁺ ALL cells. Photomicrographs (x5) of hematoxylin- and eosin-stained splenic section (A) show extensive infiltration of leukemia cells expressing CD19 antigen (B). (C and D) Corresponding sections (x25) demonstrate lack of tissue architecture due to leukemia infiltration. When isotype control antibody was used, no staining was observed (data not shown).

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