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FIGURE 3. (A) Subcutaneous LS174T (left shoulder) and C6 glioma (right shoulder) xenografts were established in nude mouse. (B) PET imaging with 18F-FDG was done 2 d before injection of 124I (10/64 planes shown). (C) Mouse was injected with 3.1 MBq (85 µCi) 124I-minibody and imaged at 18 h by PET (10/64 planes shown). Both these images (B and C) are on same color scale. (D) After 18-h scan, mouse was euthanized and frozen, and whole-body coronal sections were cut in cryostat and processed for DWBA. (E) DWBA confirms specific localization of 124I minibody to CEA-positive tumor and low levels of background activity.
