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FIGURE 1. Bar graphs indicate PET parameters, including right-to-left ratio of CBF during occlusion of MCA (A), CBF after reperfusion (B), 18F-FDG uptake as indicator of CMRGlc (C), MPDX binding to A1-Rs (D), and FMZ binding to BDZ-Rs (E), in ischemic cortex for each animal group. ANOVA and multiple comparisons between 6 pairs were performed by Bonferroni correction. CBF was reduced in all treated groups, but rate of reduction was not significantly different among them. No statistical difference among the 4 groups was found in right-to-left ratio of CBF or CMRGlc after reperfusion. MPDX binding was significantly lower in group D than in groups N, Str, and Cor. MPDX binding in group Cor was significantly lower than that in group N. FMZ binding was significantly lower in group D than in groups N and Str. Reductions of A1-Rs and BDZ-Rs were both good indicators of permanent ischemic insult, whereas reduction rate of MPDX binding to A1-Rs in group D was larger than that of FMZ binding to BDZ-Rs. *P < 0.05. **P < 0.01.
