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FIGURE 1. Four-compartment ligand-receptor model used in analysis of S12968 time-concentration curves obtained with PET. All transfer probabilities of ligand between compartments are linear, except binding probability, which depends on local association rate constant (kon), local free ligand concentration (M*f(t)/VR), and local concentration of receptor sites (Bmax - M*b(t)). PET experimental data correspond to sum of labeled ligand in 3 tissue compartments and in fraction FV of blood concentration. M*ns(t) = nonspecifically bound radioligand.
