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FIGURE 4. Electron microscopy immunogold staining in neuritic plaques in Tg(+) mouse cortex. (A) Tg(+) mice with intravenous injection of bFGF do not show presence of bFGF in brain (original magnification, x8,000). (B) Same area as in A under higher magnification (x20,000). (C) Representative electron micrograph shows that peripheral margins of neuritic plaques from animals that received bFGF intranasally contain bFGF immunogold reactivity (original magnification, x50,000). (D) bFGF is also associated with amyloid fibrils in plaque after intranasal injection (original magnification, x50,000). Arrows indicate bFGF gold labeling. Scale bars = 10 nm.
