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FIGURE 3. A 35-y-old man with bulky HD underwent 18F-FDG PET before (A), after first cycle of (B), and at completion of (C) chemotherapy. Pretherapy 18F-FDG PET images reveal radiotracer uptake in anterior mediastinum involving both hilar regions and extending into left supraclavicular region. Patient underwent chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine. 18F-FDG PET after first cycle of chemotherapy reveals residual disease in right anterior mediastinum, whereas 18F-FDG PET at completion of chemotherapy shows no evidence of residual lymphoma in corresponding regions. Disease relapsed in mediastinum after PFS of 6 mo. Images obtained after first cycle show physiologic uptake in salivary glands, oral mucosa, right shoulder (trapezius muscle), and heart.
