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FIGURE 1. Effects of AP (C5aAP) on uptake of macromolecular tracer in normal tissues of athymic (nu/nu) mice. Dose-dependent changes in uptake of 125I-IgG in various tissues and blood of athymic mice were measured 30 min after intravenous administration of 0.37 MBq 125I-IgG. Mice were given simultaneous injection of 125I-IgG and indicated doses of AP through tail vein. Results are reported as average (n = 4) ± SD. Relative uptake of 125I-IgG is calculated by dividing uptake of 125I-IgG coinjected with AP by uptake of 125I-IgG in absence of AP.
