FIGURE 2. Effects of carvedilol on myocardial fibrosis, heart size, and myocardial uptake of 125I-MIBG. Figures are representative of each group. Blue (azan staining) indicates fibrosis determined by histology. Red and blue indicate high and low myocardial uptake of MIBG determined by scintigraphy. MIBG uptake in rats with dilated cardiomyopathy was decreased not only in area of fibrosis but also in intact area. Top shows MIBG scintigram at 10 min after tracer injection. Bottom shows MIBG scintigram at 240 min after tracer injection.
