FIGURE 1. Schematic study design. Each of 2 groups of well-defined patients was mixed with 5 studies from age- and sex-matched healthy volunteers. These were compared with reference studies from, respectively, 20 and 15 healthy volunteers using visual scoring system and 3 automated methods based on anatomic standardization: predefined VOI analysis, voxelwise analysis based on region growing (BRASS), and SPM (SPM99).

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