FIGURE 1. (A) Histologic analysis of tissues in LEA rat liver showed completely normal histology. (B) Liver in LEC rats showed multiple abnormalities, including bile duct proliferation and fibrosis as seen here in portal area (P), as well as apoptosis (curved arrows), fatty change (solid straight arrow), and polyploidy (open arrow), which refers to abnormally enlarged nuclei containing multiple DNA copies. Inset shows metaphase (arrow) indicating increased mitotic activity.

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