FIGURE 5. Simulations of CGP 12177 kinetics performed with model parameters estimated during experiment 7 (Fig. 4). Symbols represent concentrations in free () and bound () ligand compartments. Solid line represents PET-measured concentration that is sum of concentration in the 2 tissue compartments and of fraction F_V of blood concentration (dotted line, which represents in this case 52% of blood time–concentration curve shown in Fig. 4).

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