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FIGURE 6. Autoradiograms of 3H-spiperone binding autoradiography in WT (A and C, +/+) and DRD2 KO (B and D, -/-) mice. (A and B) Total binding images in presence of 0.6 nmol/L 3H-spiperone and 40 nmol/L ketanserin. (C and D) Nonspecific binding images in presence of same concentration of tritiated ligand and ketanserin plus 5 µmol/L (+)-butaclamol. DRD2 binding signal was wiped out in most of caudate putamen (CPU) region in DRD2 KO mice (B) in comparison with WT counterpart (A). CTX = cerebral cortex; Acb = nucleus accumbens.
