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FIGURE 7. (A) In myocardial time-activity curves obtained after injection of 64Cu-ATSM in dog 13 at rest (protocol III), normal septal/lateral region (
) and apical region (
) show similar kinetics. Although data collection continued until 45 min, figure shows only first 12 min, for clarity. (B) In myocardial time-activity curves obtained after injection of 64Cu-ATSM in dog 13 after DOB infusion (protocol III), normal septal/lateral region () shows rapid washout kinetics but apical region () shows uptake and excellent tracer retention, indicating hypoxia. Although data collection continued until 45 min, figure shows only first 12 min, for clarity. (C-E) Graph of MBF (ratio of LADR to NLR [endocardium to epicardium]) (C) and graphs of 1/kmono retention (D) and 1/k4 retention (E) expressed as ratios between LADR and NLR at rest and stress show myocardial retention of 64Cu-ATSM for each dog in protocol III. In all cases, DOB infusion significantly increased tracer retention in damaged apical regions (P < 0.005), despite increase in MBF (Table 3).
