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FIGURE 1. Diagrammatic schema of experiments. First, DBA/1 mice are inoculated with emulsion of killed Mycobacterium tuberculosis and bovine type II collagen dissolved in incomplete Freund’s adjuvant. Autoimmune response results in polyarticular rheumatoid arthritis in 3–4 wk. Second, 99mTc-annexin V is injected, and autoradiographic images are obtained from frozen coronal sections of paw. Third, ROIs are drawn over each digit, paw pad, and Achilles tendon sheath and are used to analyze counts.
