FIGURE 2. Multiple tomographic PET images of 2 untreated patients with head and neck cancer. Corresponding axial CT scans are depicted in upper left of both image sets. (A) Supraglottic laryngeal cancer (T1 N0) shows high uptake of [18F]FDG (top row, middle) and increased blood flow (bottom row, left). Early distribution pattern of [18F]FETNIM 5–8 min from injection allows easy delineation of tumor (bottom row, middle), whereas in later phase, 120 min from injection (bottom row, right), [18F]FETNIM is distributed more evenly between tumor and ambient tissues in neck and base of mouth. PET images also show transfer of ROI (red line circling tumor) from [18F]FDG image to other PET studies. (B) Right lingual cancer (T4 N1) likewise shows high uptake of [18F]FDG (top row, middle) and high blood flow (bottom row, left). Early [18F]FETNIM image obtained 5–8 min from injection (bottom row, middle) closely resembles that of corresponding perfusion image, whereas later phase [18F]FETNIM image at 120 min (bottom row, right) shows focal uptake, especially in apex of tumor. Tumor is hardly visible in [15O]CO blood volume images (top rows, right) of both (A) and (B).
