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FIGURE 4. Metabolic comparison between aged and young monkeys. Top row represents 3-dimensional SSP of mean pixel values of cerebral metabolic rate of glucose (CMRglc, µmol/100 g/min) averaged across 6 young monkeys. Middle row represents 3-dimensional SSP mean pixel values of CMRglc across 5 aged monkeys. Bottom row represents 3-dimensional SSP of statistical z scores (Z) representing significance of regional metabolic reduction of aged group compared with young group. Images are shown as right lateral (RT.LAT), left lateral (LT.LAT), right medial (RT.MED), and left medial (LT.MED) aspects of brain. Higher pixel intensities in first 2 rows represent greater metabolic activities, and higher pixel intensities in bottom z score map indicate greater metabolic reductions associated with aging.