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Microbial Targeting of ^99mTc-Labeled Recombinant Human β-Defensin-3 in an Animal Model of Infection: A Feasibility Pilot Study

¹ Nuclear Medicine Unit, Department of Radiological Sciences, "La Sapienza" Rome University, Rome, Italy; ² Perinatology and Puericulture Unit, Laboratory of Biochemistry of Sex Hormones, Department of Gynaecological Sciences, "La Sapienza" Rome University, Rome, Italy; ³ Department of Human Physiology and Pharmacology, "La Sapienza" Rome University, Rome, Italy; ⁴ Department of Experimental Medicine and Pathology, "La Sapienza" Rome University, Rome, Italy; ⁵ Nuclear Medicine Service, Department of Veteran Affairs Health System, Ann Arbor, Michigan; and ⁶ Department of Nuclear Medicine, "S. Maria della Misericordia" Hospital, Rovigo, Italy

View larger version (80K): [in this window] [in a new window]   FIGURE 1.  Sites of tissue sampling and relative histologic findings (hematoxylin–eosin staining): normal muscle (A), S. aureus–induced infection (B), and carrageenan-induced inflammation (C). Extensive infiltration of leukocytes can be seen in B and C, whereas presence of bacteria was demonstrated in infection site only (B) by cultural examination and Gram staining of relative sample.

View larger version (15K): [in this window] [in a new window]   FIGURE 2.  Dose-dependent uptake of 99mTc-labeled HBD-3 by infection (A) and sterile inflammation (B) sites. Normal muscle (C) was used as control. Nor. = normal.