JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online March 16, 2009, 10.2967/jnumed.108.057901
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Groves, A. M.
Right arrow Articles by Ell, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Groves, A. M.
Right arrow Articles by Ell, P. J.

Idiopathic Pulmonary Fibrosis and Diffuse Parenchymal Lung Disease: Implications from Initial Experience with 18F-FDG PET/CT

Ashley M. Groves1, Thida Win2, Nicholas J. Screaton3, Marko Berovic1, Raymondo Endozo1, Helen Booth4, Irfan Kayani1, Leon J. Menezes1, John C. Dickson1 and Peter J. Ell1

1 Institute of Nuclear Medicine, University College London, London, United Kingdom; 2 Respiratory Medicine, Lister Hospital, Stevenage, United Kingdom; 3 Department of Radiology, Papworth Hospital, Cambridge, United Kingdom; and 4 Department of Thoracic Medicine, University College London Hospital, London, United Kingdom


Figure 1
View larger version (39K):
[in this window]
[in a new window]

  		FIGURE 1.  (A) Axial attenuation-corrected 18F-FDG PET. Non–attenuation-corrected 18F-FDG PET (B) and CT (C) of patient with pulmonary fibrosis. Increased 18F-FDG uptake associated with lung parenchymal abnormality is similar in appearance on both corrected and noncorrected image and therefore is not artifact induced by attenuation correction.

 

Figure 2
View larger version (71K):
[in this window]
[in a new window]

  		FIGURE 2.  Coronal fused 18F-FDG PET/CT images of 71-y-old man with clinical and conventional radiologic features of IPF. Areas of lung parenchymal abnormality on CT correspond to areas of raised 18F-FDG on PET: there is posterolateral distribution, like most cases in this study. CT component of study has been reconstructed with high-frequency algorithm and displayed to show maximum lung parenchymal detail.

 

Figure 3
View larger version (49K):
[in this window]
[in a new window]

  		FIGURE 3.  HRCT and 18F-FDG PET/CT images from 77-y-old man with newly diagnosed pulmonary fibrosis and known connective tissue disease. Lung biopsy in this patient showed histology to be nonspecific interstitial pneumonitis. HRCT image (A) shows multiple areas of honeycombing, in keeping with established fibrosis. Fused 18F-FDG PET/CT images (B and C) show that lung parenchymal abnormalities identified on HRCT are associated with increased 18F-FDG uptake on PET (C).

 

Figure 4
View larger version (70K):
[in this window]
[in a new window]

  		FIGURE 4.  HRCT (A) and 18F-FDG PET (B) images from 74-y-old man with newly diagnosed IPF. HRCT image (A) shows typical pattern of usual interstitial pneumonitis. Areas of most intense 18F-FDG uptake correspond to areas of parenchymal honeycombing on CT.

 

Figure 5
View larger version (5K):
[in this window]
[in a new window]

  		FIGURE 5.  Interobserver agreement as assessed by Bland–Altman statistics.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2009 by the Society of Nuclear Medicine.