JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online January 21, 2009, 10.2967/jnumed.108.056556
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, N.
Right arrow Articles by Yu, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, N.
Right arrow Articles by Yu, J.

PET-Based Biodistribution and Radiation Dosimetry of Epidermal Growth Factor Receptor–Selective Tracer 11C-PD153035 in Humans

Ningbo Liu1, Minghuan Li2, Xiaoyu Li3, Xue Meng2, Guoren Yang4, Shuqiang Zhao4, Yi Yang5, Li Ma4, Zheng Fu4 and Jinming Yu1,2

1 Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; 2 Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, China; 3 Department of Pathophysiology, Nanjing Medical University, Nanjing, China; 4 PET-CT Center, Shandong Cancer Hospital and Institute, Jinan China; and 5 Department of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China


Figure 1
View larger version (96K):
[in this window]
[in a new window]

  		FIGURE 1.  Representative coronal images of whole-body biodistribution of 11C-PD153035 30–40 min after injection (292.3 MBq) in healthy volunteer. Intense tracer uptake was observed in liver, gallbladder, urinary bladder, and kidneys. (A) CT image. (B) PET image.

 

Figure 2
View larger version (90K):
[in this window]
[in a new window]

  		FIGURE 2.  11C-PD-153035 PET/CT scan in patient with NSCLC of left lung. (A) Coronal CT image. (B) Coronal PET image. (C) Transaxial CT image. (D) Transaxial PET image.

 

Figure 3
View larger version (14K):
[in this window]
[in a new window]

  		FIGURE 3.  (A) Time–activity curves for 11C-PD153035 in serial PET of gallbladder, bladder, small intestine, and ureter. Data points indicate measured mean activities and were not corrected for radioactive decay. (B) Time–activity curves for 11C-PD153035 in serial PET of liver, kidneys, brain, lungs, heart, and spleen. Data points indicate measured mean activities and were not corrected for radioactive decay.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2009 by the Society of Nuclear Medicine.