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First published online January 21, 2009, 10.2967/jnumed.108.056341
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Myocardial β-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy

Masanao Naya1, Takahiro Tsukamoto1, Koichi Morita2, Chietsugu Katoh3, Kenichi Nishijima4, Hiroshi Komatsu1, Satoshi Yamada1, Yuji Kuge4, Nagara Tamaki2 and Hiroyuki Tsutsui1

1 Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 2 Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 3 Department of Health Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan; and 4 Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan


Figure 1
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  		FIGURE 1.  Changes in NYHA functional class (A) and LVEF (B) before and after 20 mo of carvedilol treatment.

 

Figure 2
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  		FIGURE 2.  Relationship between {Delta}LVEF-carvedilol (CARV) and baseline myocardial β-AR density.

 

Figure 3
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  		FIGURE 3.  Relationship between {Delta}LVEF-carvedilol (CARV) and {Delta}LVEF-dobutamine (DOB).

 




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