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First published online December 17, 2008, 10.2967/jnumed.108.056085
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Validation of Gated Blood-Pool SPECT Regional Left Ventricular Function Measurements

Kenneth J. Nichols1,2, Andrew Van Tosh2, Yi Wang2, Christopher J. Palestro1 and Nathaniel Reichek2

1 Division of Nuclear Medicine and Molecular Imaging, North Shore–Long Island Jewish Health System, Manhasset and New Hyde Park, New York; and 2 Research Department, St. Francis Hospital, Roslyn, New York


Figure 1
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  		FIGURE 1.  MR images of 75-y-old male patient with history of congestive heart failure and hypertension with severe LV and RV dysfunction and abnormal LV EF (23%) at ED (A) and ES (B). Manually drawn epicardial and endocardial outlines are superimposed on images.

 

Figure 2
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  		FIGURE 2.  Screens of cines used to visually analyze BP-gated SPECT regional WM abnormalities for same patient in Figure 1 at ED (A) and ES (B).

 

Figure 3
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  		FIGURE 3.  Polar map of BP-gated SPECT LV regional EF (percentage) for patient in Figure 1.

 

Figure 4
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  		FIGURE 4.  BP measurement of global LV EF vs. cardiac MRI–quantified global LV EF. CMR = cardiac MRI.

 

Figure 5
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  		FIGURE 5.  Receiver-operating-characteristic curves to predict LV segments with abnormal WM as seen on cardiac MRI, for AQ BP-gated SPECT EF, initial visual assessment (V1), and second visual assessment (V2) for all territories (A) and for LCX (B), LAD (C), and RCA (D) territories only.

 




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