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Quantification of Left Ventricular Volumes and Ejection Fraction in Mice Using PET, Compared with MRI

¹ Department of Nuclear Medicine, University Hospital Münster, Münster, Germany; ² European Institute of Molecular Imaging, University of Münster, Münster, Germany; and ³ Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

View larger version (75K): [in this window] [in a new window]   FIGURE 1.  Mid-ventricular (solid line) and endo- and epicardial contours (dashed lines) derived by LV segmentation algorithm are superimposed on end-diastolic and end-systolic long-axis (A and D, respectively) and short-axis (B and E) PET images. Additionally, 3-dimensional representation of endocardial contour at end-systole (solid surface with color-coded 18F-FDG uptake) and at end-diastole (meshgrid) is shown from inferior (C) and anterior (F) views.

View larger version (48K): [in this window] [in a new window]   FIGURE 2.  MRI (top) and PET (bottom) images of mouse without infarction (A, B, E, and F) and of mouse with extended infarction (C, D, G, and H). Shown are mid-ventricular long-axis (A, C, E, and G) and short-axis (B, D, F, and H) images. One end-diastolic gate was used for PET image reconstruction.

View larger version (21K): [in this window] [in a new window]   FIGURE 3.  Correlation and orthogonal regression analysis for EDV (A), ESV (C), and EF (E) calculated by PET and MRI. Scatter plot and regression line are displayed; slope and y-intercept of regression curve and R value are provided in inserts. Values are shown for occlusion group (•), for ischemia–reperfusion group (), and for control group (+). Agreement analysis of PET and MRI according to Bland–Altman for EDV (B), ESV (D), and EF (F) is displayed. Difference (diff) of measurements obtained by PET and MRI is plotted against mean. Solid horizontal line is located at mean value; dashed lines are located 2 SDs above and below mean.