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Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?

¹ National Institute on Aging, National Institutes of Health, Bethesda, Maryland; ² Department of Radiology, Johns Hopkins University, Baltimore, Maryland; ³ Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania; ⁴ Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; ⁵ Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland; and ⁶ Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland

View larger version (6K): [in this window] [in a new window]   FIGURE 1.  Scatterplot of association between age and mean cortical DVR. With 2-group K-mean cluster analysis, 2 clusters of individuals were identified: one with higher 11C-PIB retention and another with lower 11C-PIB retention, as determined by mean cortical DVR.

View larger version (43K): [in this window] [in a new window]   FIGURE 2.  Longitudinal rCBF increases (red) and decreases (blue) over 8-y interval in group with high amyloid deposition, compared with group with low amyloid deposition. In lower row, differences in longitudinal rCBF changes are overlaid on selected axial images showing voxel-based differences in amyloid deposition between high– and low–11C-PIB groups.