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Gene Expression Patterns and Tumor Uptake of ¹⁸F-FDG, ¹⁸F-FLT, and ¹⁸F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

¹ Department of Nuclear Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany; ² Department of General Surgery and Thoracic Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany; ³ Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ⁴ Department of Anatomy II Experimental Morphology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ⁵ Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and ⁶ Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany

View larger version (21K): [in this window] [in a new window]   FIGURE 1.  Tumor uptake of 18F-FDG (A), 18F-FLT (B), and 18F-FEC (C) in mouse 1 with a BxPc3 tumor (row 1: MRI; row 2: PET; row 3: PET/MRI). Tumor is readily visible in abdomen on MR images (arrows). (A) There is no increased 18F-FDG uptake within tumor; hot spots are 18F-FDG activity within kidneys. (B) Tumor is readily visible, showing intense 18F-FLT uptake that is higher than in any other organ. (C) There is no 18F-FEC uptake within tumor; liver and kidneys show pronounced tracer uptake.

View larger version (18K): [in this window] [in a new window]   FIGURE 2.  Expression of genes involved in membrane transport or metabolism of 18F-FDG in pancreatic cancer cell lines PancTuI, Colo357, and BxPc3, compared with expression in normal pancreatic duct cells (n = 13) and PDAC cells (n = 19) as determined by microarray analysis. Mean expression level is marked by a line.

View larger version (14K): [in this window] [in a new window]   FIGURE 3.  Expression of genes involved in membrane transport or metabolism of 18F-FLT in pancreatic cancer cell lines PancTuI, Colo357, and BxPc3, compared with expression in normal pancreatic duct cells (n = 13) and PDAC cells (n = 19) as determined by microarray analysis. Mean expression level is marked by a line.

View larger version (21K): [in this window] [in a new window]   FIGURE 4.  Expression of genes involved in membrane transport or metabolism of 18F-FEC in pancreatic cancer cell lines PancTuI, Colo357, and BxPc3, compared with expression in normal pancreatic duct cells (n = 13) and PDAC cells (n = 19) as determined by microarray analysis. Mean expression level is marked by a line.